treatment of COVID-19 patients – Communicable Diseases Research

Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds

양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme

고충실도 CRISPR-Cas12 효소를 사용한 COVID-19 변이체 탐지

Article

Published on 2022-07-202022-09-11
Journal: Journal of Clinical Microbiology
[Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제,

[키워드] Analysis Assay validation circulating variant clinical sample clinical samples Concordance COVID-19 COVID-19 patient COVID-19 patients CRISPR CRISPR-Cas12 detection DETECTR Diagnostic method enzyme Enzymes faster followed by Genome sequencing guide RNAs identify infection control isothermal amplification L452R Laboratory test Laboratory tests LAMP Loop-mediated isothermal amplification Mutation mutations N501Y nucleotide omicron Patient polymorphism public health real-time RT-PCR RNAs SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Sequencing single nucleotide Single nucleotide polymorphism SNP Surveillance target the SARS-CoV-2 Treatment treatment of COVID-19 patients utility variant variants Viral mutations viral mutations. whole-genome sequencing
[DOI] 10.1128/jcm.00261-22 PMC 바로가기 [Article Type] Article

Suspect screening of wastewaters to trace anti-COVID-19 drugs: Potential adverse effects on aquatic environment

항-COVID-19 약물 추적을 위한 폐수 의심 스크리닝: 수생 환경에 대한 잠재적인 역효과

Article

Published on 2022-06-102022-09-11
Journal: The Science of the total environment
[Category] COVID19(2023년), SARS, 치료기술, 치료제,

[키워드] adverse effect antibiotic Antibiotic resistance Antibiotics antiviral drugs approach Aquatic ecosystems aquatic environment average Azithromycin Care ciprofloxacin Cluster Compound conducted COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic COVID-19 patients COVID-19 treatment deaths drug drugs Drugs consumption ecological eight Epidemiology European Evidence evidenced Health highest hospital Hydroxychloroquine lack liquid Liquid chromatography list lombardy management mass mass spectrometry metabolite pandemic plants positively correlated Potential protocol receiving Resolution risk SARS-CoV-2 SARS-CoV-2 pandemic Spectrometry starting Suspect screening the SARS-CoV-2 Therapeutic treatment Toxicity Treatment treatment of COVID-19 patients Viral resistance Wastewater-based epidemiology. water water bodies water body were measured
[DOI] 10.1016/j.scitotenv.2022.153756 PMC 바로가기 [Article Type] Article

Anakinra treatment efficacy in reduction of inflammatory biomarkers in COVID-19 patients: A meta-analysis

COVID-19 환자에서 염증성 바이오마커 감소에 대한 아나킨라 치료 효능: 메타 분석

Meta-Analysis

Published on 2022-06-012022-09-11
Journal: Journal of Clinical Laboratory Analysis
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] acute-phase reactant Admission Anakinra analyzed anti-inflammatory agent C-reactive protein C-reactive protein (CRP Care Cochrane Central concentrations conducted COVID-19 COVID-19 patients CRP CRP value CRP values D-dimer database dimer Efficacy elevated ferritin Follow-up hematological Inflammatory Inflammatory biomarker inflammatory biomarkers interleukin interleukin-1 Laboratory males Manger marker mean difference mean value Meta-analysis notable Patient Protein reduce mortality reduced reduction review SARS-CoV-2 serum Serum ferritin serum ferritin. SMD statistically the mean Treatment treatment of COVID-19 patients trials Web of Science
[DOI] 10.1002/jcla.24434 PMC 바로가기 [Article Type] Meta-Analysis

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

Clofoctol은 SARS-CoV-2 복제를 억제하고 쥐의 폐 병리를 감소시킵니다

Article

Published on 2022-05-192022-09-11
Journal: PLoS Pathogens
[Category] COVID19(2023년), SARS, 신약개발, 치료제,

Profiling of SARS-CoV-2 Subgenomic RNAs in Clinical Specimens

임상 표본에서 SARS-CoV-2 서브게놈 RNA의 프로파일링

Article

Published on 2022-04-272022-09-11
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제,

[키워드] accessory protein age applied association canonical canonical sgRNA canonical sgRNAs changes in Characteristics clinical Clinical characteristics clinical samples collected COVID-19 COVID-19 patient COVID-19 patients deleted diagnostic discontinuous transcription event expression profile followed by Frame frameshift full-length genomic RNA identify independent Infection Isolation large cohort life cycle majority management marker MONITOR monitoring Next-generation sequencing Numerous Open reading frame ORF10 ORF3a ORF6 ORF7a ORF7b ORF8 Patient PCR positive Potential biomarker potential biomarkers produced profile Profiling progression Protein provide real-time RT-PCR respiratory respiratory sample Respiratory samples RNA RNA-Seq RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sgRNA SARS-CoV-2 sgRNAs sgRNA sgRNAs specimen specimen collection Stool stool samples subgenomic RNA subgenomic RNAs subgenomic. the patient transcript translation Treatment treatment of COVID-19 patients undetectable variant Viral load
[DOI] 10.1128/spectrum.00182-22 PMC 바로가기 [Article Type] Article

Theophylline: Old Drug in a New Light, Application in COVID-19 through Computational Studies

테오필린: 새로운 시각으로 보는 구약, 전산 연구를 통한 COVID-19 적용

Review

Published on 2022-04-092022-09-11
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] activated adjuvant Antiviral antiviral activity application approach approaches Combination Compound Computational methods COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease down-regulate drug Drug discovery drugs effective Effects immunological immunomodulatory immunomodulatory effects IMPROVE Inflammatory involved LIGHT management mechanisms molecular molecular docking network pharmacology New pathophysiology pharmacokinetic pharmacological treatment Quantitative quantitative systems pharmacology respiratory diseases SARS-CoV-2 SARS-CoV-2 virus Simulation study target the disease the SARS-CoV-2 virus theophylline theophylline. treat Treatment treatment of COVID-19 patients variant
[DOI] 10.3390/ijms23084167 PMC 바로가기 [Article Type] Review

Novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2

인간 베타 코로나바이러스 HCoV-OC43 및 SARS-CoV-2에 대한 PAD 억제제의 새로운 항바이러스 활성

Article

Published on 2022-04-012022-09-11
Journal: Antiviral Research
[Category] COVID19(2023년), SARS, 신약개발, 치료제,

[키워드] African green monkey Antiviral antiviral activity Antiviral agents Antiviral compounds beta-coronavirus calcium Cell Citrullination coronavirus COVID-19 patients develop effective Efficacy enzyme Factor family fetal fibroblast green monkey HCoV HCoV-OC43 HCoVs highlight Host-targeting antivirals Infection inhibitor inhibitors inhibitory activity kidney likelihood lung New coronavirus novel OC43 Peptidyl-arginine deiminases Protein rationale Replication repurposing SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication SARS-CoV-2. specific inhibitor strain suppresse transcriptional activation Treatment treatment of COVID-19 patients Vero-E6 cells viral replication
[DOI] 10.1016/j.antiviral.2022.105278 PMC 바로가기 [Article Type] Article

COVID-19 disease diagnosis from paper-based ECG trace image data using a novel convolutional neural network model

새로운 컨볼루션 신경망 모델을 사용하여 종이 기반 ECG 추적 이미지 데이터에서 COVID-19 질병 진단

Article

Published on 2022-03-012022-09-11
Journal: Physical and engineering sciences in medicine
[Category] SARS, 치료기술,

[키워드] Abnormalities abnormality Accuracy addition alternative method alternative methods AUC value binary classification cardiovascular cardiovascular diseases Cardiovascular diseases diagnosis cardiovascular system caused clinical clinician Convolutional neural network Convolutional neural networks COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 infected patient COVID-19 infected patients COVID-19 pandemic COVID-19 patients COVID-19 virus deep deep learning detect Diagnosis diagnosis of COVID-19 Diagnostic method disease ECG Electrocardiography heartbeat Impact infected patients limitations machine machine learning Machine learning. Medical imaging multi-classification Myocardial Myocardial infarction network model Neural normal pandemic PCR tests Respiratory system RT-PCR test shown Treatment treatment of COVID-19 patients
[DOI] 10.1007/s13246-022-01102-w PMC 바로가기 [Article Type] Article

Application and Validation of SARS-CoV-2 RBD Neutralizing ELISA Assay

SARS-CoV-2 RBD 중화 ELISA 분석의 적용 및 검증

Article

Published on 2022-02-282022-09-11
Journal: Archives of Razi Institute
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] 95% CI absorbance acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme anti-RBD anti-SARS-CoV-2 IgG antibody application approach biosafety clinical evaluation Coefficient of determination Cohort Concentration convalescent convalescent plasma coronavirus disease Coronavirus disease 2019 Coronavirus-2 correlation COVID-19 COVID-19 patients COVID-19 vaccine COVID-19 vaccines demonstrated detect different time point different time points disease severity domain Donor Efficiency ELISA ELISA assay enzyme-linked immunosorbent enzyme-linked immunosorbent assay gold gold standard healthy individual healthy individuals host cell host cell receptor house human Angiotensin-converting enzyme individual Interaction Laboratory live virus live viruses log methodology NAb NAbs nAbs. Neutralizing Neutralizing antibodies neutralizing antibody optical optical density pandemic processed Protein purified Quantitative RBD respiratory Safe SARS-CoV-2 SARS-CoV-2 nAbs SARS-CoV-2 RBD SARS-COV-2-RBD neutralizing ELISA assay sensitivity Seroprevalence serum sample serum samples specificity Spike protein standard curve statistical the spike protein Treatment treatment of COVID-19 patients validation viruses
[DOI] 10.22092/ARI.2021.356677.1890 PMC 바로가기 [Article Type] Article